hepatoprotective effects of arbutin against liver damage induced by carbon tetrachloride in rats

conclusions the results of this study showed that arbutin may protect the liver against ccl4-induced oxidative damage in rats. this hepatoprotective effect might be correlated with the antioxidant and free radical scavenger effects of arbutin. results treatment with ccl4 for 28 d decreased the levels of total protein and albumin and increased the level of bilirubin and lipid peroxidation. arbutin treatment raised the level of albumin and lowered the lipid peroxidation to normal levels. necrosis and fibrosis were observed in the liver tissue of ccl4-injected rats, and the administration of arbutin had a protective effect on the liver tissue. methods sixty-three wistar rats were divided into nine groups. groups i and ii were the normal control groups. group iii, the hepatotoxic group, was given ccl4. groups iv, vi, and viii received different dosages of arbutin along with ccl4. groups v, vii, and ix were administered different dosages of arbutin. the albumin content, total protein, and bilirubin were assayed to determine their serum and antioxidant levels; lipid peroxidation was assessed in the serum and liver tissue. histological studies were carried out to confirm the biochemical results. background the antioxidant and anti-inflammatory effects of arbutin protect against a number of diseases. objectives the present study evaluated the protective effect of arbutin against carbon tetrachloride (ccl4)-induced hepatotoxicity in rats.